Agradecemos la gentileza del Dr. Oscar. D. Bruno por el aporte de este valioso material y nos congratulamos por su generoso compromiso para futuros envíos, muchas gracias Maestro. Existe la idea generalizada de que la acromegalia es una enfermedad benigna e infrecuente. Sin embargo, el paciente acromegálico ve comprometida su vida a causa de complicaciones cardiovasculares y metabólicas. Por otra parte, trabajos recientes muestran que su frecuencia parece mucho mayor que lo supuesto previamente. Dado que los signos y síntomas de la enfermedad se instalan lenta e insidiosamente, existe una demora considerable en su diagnóstico. Habitualmente, los pacientes han consultado diversos...

Agradecemos la gentileza del Dr. Oscar. D. Bruno por el envío de este valioso material. The main reason that led me to write this paper was the presentation of a poster at the 12 International Thyroid Conference in Kyoto, Japan (2000), about “Complications of Thyroidectomy in Patients with Radiation-Induced Thyroid Neoplasms”. This poster was illustrated with a picture of the well-known opera singer Amelita Galli-Curci. At that time, I became aware of what was called among American neck surgeons “the nerve of Galli-Curci”. But, what was the story behind it?    

Agradecemos la gentileza del Dr. Oscar. D. Bruno por el envío de este valioso material. The role of mechanical forces influencing the growth of a pituitary adenoma is poorly understood. In this paper we report the case of a young man with hyperprolactinaemia and an empty sella secondary to hydrocephalia, who developed a macroprolactinoma following the relief of high intraventricular pressure. Learning points: {jb_bluebox}• The volume of a pituitary tumour may be influenced not only by molecular but also by local mechanical factors. • Intratumoural pressure, resistance of the sellar diaphragm and intracranial liquid pressure may play a role in the final size of...

Nuestro agradecimiento al Dr. Oscar. D. Bruno por compartir este valioso material. Abstract: Context Hyporituitarism in adults is known to be associated with deleterious effects on body composition, lipid profile and quality of life (QoL). This was attributed to GH deficiency. The potential role of glucocorticoid overreplacement had never been investigated. Objective To investigate whether reduction in glucocorticoid replace- ment dose to more physiological one could ameliorate the ‘‘AO-GHD’’-attributed symptomatology in patients with hypopituitarism. Design Eleven patients with panhypopi- tuitarism taking 20–30 mg/day of hydrocortisone, but on no GH replacement were switched to 10–15 mg of hydrocortisone daily. Both basally and...

Agradecemos la gentileza del Dr. Oscar. D. Bruno por el aporte de este valioso material. La amiodarona es un análogo estructural de la hormona tiroidea, y algunas de sus propiedades antiarrítmicas como así también su toxicidad son atribuibles a su interacción con los receptores nucleares de las hormonas tiroideas. Por ser muy lipofílica, la amiodarona se concentra en muchos tejidos y se elimina, por consecuencia, muy lentamente. Se emplea preferentemente para el tratamiento de arritmias graves tales como ibrilación y taquicardia ventriculares. Otras indicaciones incluyen la ibrilación auricular y el aleteo, la insuiciencia cardíaca congestiva grave, la prevención de la ibrilación...

Agradecemos la gentileza del Dr. Oscar. D. Bruno por el envío de este valioso material. Insulinomas are pancreatic neuroendocrine tumors (pNET), usually benign. Akt/p27kip1 is an intracellular pathway overexpressed in many pNET. There are no data regarding its expression in human insulinomas. We aimed to investigate the expression of Akt and p27kip1 in 24 human insulinomas and to compare them to their expression in normal surrounding islets. Staining was performed on embedded paraffin tissue using polyclonal antibodies against total Akt, p-Akt, p27kip1, and pp27kip1. p-Akt was the predominant form in insulinomas; they presented lower Akt and p-Akt expression than normal islets...

Agradecemos la gentileza del Dr. Oscar. D. Bruno por el envío de este valioso material. Evidence-based treatment guidelines have undoubtedly advanced medical practice and supported optimal management of acromegaly, but their application may be hampered by limited access to the latest treatment options.    

Agradecemos la gentileza del Dr. Oscar. D. Bruno por el envío de este valioso material. We found a high prevalence of thyroid autoimmunity in our patients with acromegaly as compared to the normal population. Thyroid autoimmunity seems to be an additional mechanism for the development of thyroid disorders in acromegaly.